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Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. After 2 weeks of completion of induction therapy, patients receive chemoradiation.Drugs used in chemotherapy, such as cisplatin, etoposide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. ARM III (induction therapy): Patients receive crizotinib PO twice daily (BID) for up to 12 weeks.HPV, also called human papillomavirus, is a group of more than 150 related viruses.More than 40 of these viruses can be easily spread through direct skin-to-skin contact during vaginal, anal, and oral sex.It is not yet known whether giving erlotinib hydrochloride is more effective than crizotinib with chemoradiation therapy in treating patients with non-small cell lung cancer. To assess whether patients with unresectable local-regionally advanced non-small cell lung cancer (NSCLC) treated with targeted agents based on molecular characteristics have a longer progression-free survival than those treated with standard care therapy alone. Patients who have had no response (partial or complete) after 6 weeks undergo concurrent chemoradiation therapy immediately. OUTLINE: Patients are randomized to 1 of 4 treatment arms.

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